Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10

Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10

Blog Article

Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies.However, these vaccines have demonstrated limited clinical results.Although the low immunogenicity 5-HTP of tumor antigens used and the presence of tumor-associated suppressive factors may in part account for these results, intrinsic vaccine-related factors may also be involved.

Vaccines modulate DC functions by inducing activating and inhibitory signals that determine ensuing T Carrying Case cell responses.In this mini review, we focus on IL-10, inhibitory cytokine induced in DC upon vaccination, which defines a suppressive cell subset, discussing its implications as a potential target in combined vaccination immunotherapies.